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Ck-mb
| Catalog # | Name | Size | Price | Qty | |
|---|---|---|---|---|---|
| CK1296 |
Ck-mb
Method: Immunoinhibition |
19 x 2.5ml | £113.56 |
Specification
| Format: | Lyophilised |
| Assay Range : | 23.5 - 2044 U/L |
| Working Stability 15-25 °C: | _ |
| Working Stability 2-8 °C: | 21 days |
| Request Kit Insert |
Enquiry / Requests
Payment Options
Online: We accept all major credit cards including
Offline: Please call us on +44 (0) 28 9442 2413 or email us at marketing@randox.com
Intended Use
For the quantitative in vitro determination of CK-MB in serum and plasma. This product is suitable for both manual and automated use.
Clinical Significance
Creatine Kinase (CK) is internationally accepted as a sensitive and specific indicator of acute myocardial infarction (AMI). There are 3 iso-enzymes of CK, CK-MM, CK-MB and CK-BB. CK-BB is produced by the brain in very small insignificant amounts. CK-MM is produced by the skeletal and heart tissue and CK-MB is produced by the heart muscle.
In the vast majority of cases CK activity rises within 6 hours of an acute infarction. After about 20 hours maximum CK values are observed. The CK activity generally returns to normal between the fourth and fifth day post- infarction.
Determination of CK activity in both plasma and serum can therefore provide a sensitive and specific marker for myocardial infarction, hyperthyroidism, kidney disease, cerebrovascular accidents and skeletal muscle diseases such as muscular dystrophy.
Elevated levels of CK are usually associated with damage to the heart or other muscles. It may also indicate excessive exercise or heavy use of the muscles.
Principle
Immunoinhibition Assay: An antibody is incorporated in the CK reagent. This antibody will bind to and inhibit the activity of the M subunit of CK-MB. This means that only the activity of the B subunit in serum is measured. If the activity is multiplied by a factor of 2, it will give the activity of CK-MB in serum.