Alt (gpt) (liquid) (mono reagent) assay
| Product | Method | Size | Catalog | Price | Quantity |
| Alt (gpt) (liquid) (mono reagent) assay | IFCC | 6x20.5ml | AL3875 | £60.40 | |
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- Format
Liquid ready to use - Assay Range
9.7 - 603U/L - Working Stability 15-25 °C
_ - Working Stability 2-8 °C
Stable to expiry - Material Safety Data Sheets
Intended Use
For the quantitative in vitro determination of Alanine Aminotransferase (ALT) activity in serum and plasma. This product is suitable for use on RX Seriesinstruments which includes the Rx Daytona and the Rx Imola.
Clinical Significance
The aminotransferases are a group of enzymes that catalyse the inter-conversion of amino acids and a oxoacids by transferring amino groups. The enzyme ALT (alanine aminotransferase or glutamate pyruvate transaminase) has been found to be in highest concentrations in the liver, with decreasing concentrations found in the kidneys, heart, skeletal muscle, pancreas, spleen and lung tissue respectively .
ALT measurements are used in the diagnosis and treatment of certain liver diseases (e.g. viral hepatitis and cirrhosis) and heart diseases. Extremely elevated levels of ALT can indicate acute hepatitis with moderately high levels indicating chronic hepatitis.
Elevated levels of the transaminases can also be indicative of myocardial infarction, hepatic disease, muscular dystrophy and organ damage. Elevated levels of ALT in serum is rare except in parenchymal liver disease, since ALT is a more liver specific enzyme.
ALT is often tested in combination with AST as part of a liver panel with ALT levels being higher in most types of liver disease.
Principle
This is a modification of the optimized standard method according to the recommendations of the IFCC.
α-oxoglutarate reacts with L-alanine in the presence of ALT to form L-glutamate plus pyruvate. The indicator reaction utilizes the pyruvate for a kinetic determination of NADH consumption.
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