Amylase/amylase pancreatic (liquid) assay
| Product | Method | Size | Catalog | Price | Quantity |
| Amylase/amylase pancreatic (liquid) assay | EPS | R2 6x100ml | AY7607 | £5333.00 | |
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- Material Safety Data Sheets
Intended Use
For the quantitative in vitro determination of a-amylase in serum, plasma and urine. This product is suitable for use on the Hitachi 747 and Hitachi Modular D.
Clinical Significance
The amylases are a group of hydrolases that split complex carbohydrates constituted of ω-D-glucose units. The two recognised types of amylases are ß-amylase (e.g. plant and bacterial exoamylase) and human ω-amylases which can attack the ω-1, 4-linkage anywhere along a polyglucan chain. Human ω-amylase consists of two major isoenzymes, pancreatic and salivary, which are encoded by two different genes. Pancreatic amylase is synthesised only in pancreatic tissue by acinar cells, however the salivary amylase is found in numerous locations, such as salivary glands and female genital, pulmonary and malignant tissues.
Amylase measurements are used primarily for the diagnosis and treatment of pancreatitis (severe inflammation of the pancreas) as well as pancreatic diseases. Amylase levels rise quickly at the start of a pancreatitis attack and fall after around 2 days. Elevated levels may also be associated with cancer of the pancreas, a perforated ulcer, gallbladder disease, mumps or ectopic pregnancy.
Principle
The method uses ethylidene blocked p-nitrophenyl-maltoheptaoside as substrate. The indicator enzyme α-glucosidase, used to release the p-nitrophenol, is also employed in the method. The terminal glucose of the substrate is chemically blocked preventing cleavage by the indicator enzymes.
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