Cholinesterase (butyryl) assay
| Product | Method | Size | Catalog | Price | Quantity |
| Cholinesterase (butyryl) assay | Colorimetric | R1 6x40, R2 6x9ml | CE7944 | £119.75 | |
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- Format
Lyophilised - Assay Range
Linear up to 10000U/L - Working Stability 15-25 °C
4 days - Working Stability 2-8 °C
6 weeks - Material Safety Data Sheets
Intended Use
For the quantitative in vitro determination of Butyryl Cholinesterase in serum and plasma. This product is suitable for use on the Hitachi 704, 717, 902 and 911/912.
Clinical Significance
Cholinesterase refers to a family of enzymes namely pseudocholinesterase and acetylcholinesterase that catalyse the hydrolysis of acetylcholine into choline and acetic acid.
Individuals deficient in the enzyme pseudocholinesterase are extremely sensitive to the muscle relaxant succinylcholine which is often used during surgery. Pseudocholinesterase is responsible for metabolizing local anesthetic; a deficiency therefore decreases safety during surgery and increases the risk of systemic effects such as prolonged apnea and respiratory difficulties.
Cholinesterase levels in the blood can also provide and indication of liver function and insecticide poisoning. Levels are approximately half in patients with acute/chronic hepatitis, liver cirrhosis and carcinoma.
Principle
Butyryl Cholinesterase hydrolyses butyrylthiocholine to give thiocholine and butyrate. The reaction between thiocholine and DTNB gives 2-nitro-5-mercaptobenzoate, a yellow compound which can be measured at 480 nm.
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