Complement component 4 (liquid) assay
| Product | Method | Size | Catalog | Price | Quantity |
| Complement component 4 (liquid) assay | Immunoturbidimetric | R1 3 x 20ml, R2 3 x 6ml | CM3846 | £299.70 | |
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- Format
Liquid ready to use - Assay Range
3.41 - 663mg/dl - Working Stability 15-25 °C
_ - Working Stability 2-8 °C
Stable to expiry - Material Safety Data Sheets
Intended Use
For the quantitative in vitro determination of Complement C4 concentration in serum. This product is suitable for use on the RX Series instruments which includes the Rx Daytona and Rx Imola. Applications are also available for a wide range of other analysers.
Clinical Significance
Complement is a complex biological system which works in conjunction with antibodies and other factors to protect the body from invasion by pathogens. When activated by either the classical or alternative pathway Complement acts on biological membranes and may cause cell death. The human complement cascade consists of several distinct plasma proteins.
Complement C3 and Complement C4 levels are important in determining inherited or acquired deficiencies. Conversely, levels may rise in a variety of inflammatory and necrotic disorders as part of the acute-phase plasma protein response.
Complement can help diagnose and monitor autoimmune diseases, including systemic lupus and vasculitis as well as erythematosus, rheumatoid arthritis and angiodema. Decreased levels of complement may be inherited and can lead to recurrent infection or increased risk of autoimmune diseases. Elevated levels of complement are usually seen during acute of chronic inflammation.
Principle
Sample is reacted with a buffer containing antibody specific for human complement C4 (β1E-globulin). The absorbance (340 nm) of the resulting turbid solution is proportional to the concentration of C4 in the sample. By constructing a standard curve from the absorbance of standards, C4 concentration of sample can be determined.
- Various
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