G6p-dh assay
| Product | Method | Size | Catalog | Price | Quantity |
| G6p-dh assay | UV | R1 1 x 100ml, R2 1 x 2ml | PD410 | £42.75 | |
| Shipping costs will be added at the checkout stage, click here for charges. | |||||
- Format
Lyophilised - Assay Range
154 - 4303U/L - Working Stability 15-25 °C
_ - Working Stability 2-8 °C
28 days - Material Safety Data Sheets
Intended Use
For the quantitative in vitro determination of Glucose-6-Phosphate Dehydrogenase in erythrocytes. This product is suitable for both manual and automated use.
Clinical Significance
The enzyme Glucose-6-Phosphate Dehydrogenase (G6PDH) plays a major role in protecting the red blood cells from oxidative damage which can alter the structure causing them to lyse.
G6PDH deficiency is one of the most common enzyme deficiencies in the world, it is a genetic disorder resulting from one or more mutations in the gene coding for G6PDH. Mutation can affect the stability or functionality of the enzyme and ultimately leads to decreased enzyme activity.
Haemolytic anaemia is perhaps the most common problem resulting from G6PDH deficiency and occurs when the red blood cells are destroyed at an accelerated rate before the body can replace them. G6PDH deficiency may also be associated with jaundice.
Principle
The enzyme activity is determined by measurement of the rate of absorbance change at 340 nm due to the reduction of NADP+.
- Various
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