Hba1c/hb (liquid) assay
| Product | Method | Size | Catalog | Price | Quantity |
| Hba1c/hb (liquid) assay | LEI | R1 3 x 14ml, R2 3 x 14ml | HA3830 | £1328.10 | |
| Shipping costs will be added at the checkout stage, click here for charges. | |||||
- Format
Liquid - Assay Range
0.25 - 2.4g/dl - Working Stability 15-25 °C
_ - Working Stability 2-8 °C
Stable to expiry - Material Safety Data Sheets
Intended Use
A haemoglobin A1c test system is a device intended for the quantitative in vitro determination of haemoglobin A1c concentration in whole blood. This product is suitable for use on RX Series instruments which includes the Rx Daytona and Rx Imola.
Clinical Significance
The measurement of HbA1c is used in the long-term monitoring of diabetes mellitus. This assay should not be used in the diagnosis of diabetes mellitus or for day to day glucose monitoring.
Diabetes Mellitus is a disease associated with poor glycaemic control. Numerous clinical studies, including the Diabetes Control and Complications Trial, have shown that diabetes related complications may be reduced by the long term monitoring and tight control of blood glucose levels.
In the diabetic patient where blood glucose levels are abnormally elevated the level of HbA1c also increases, the reason for this is that HbA1c is formed by the nonenzymatic glycation of the N-terminus of the β-chain of haemoglobin A0.
The level of HbA1c is proportional to the level of glucose in the blood and has been widely accepted as an indicator of the mean daily blood glucose concentration over the preceding 6-8 weeks. It is therefore, a long term indicator of diabetic control, whereas, the measurement of blood glucose is only a short term indicator.
Principle
Both the concentration of HbA1c and the concentration of total haemoglobin are measured. The reported HbA1c result is calculated as a % of the total haemoglobin concentration.
The HbA1c and total haemoglobin values generated in this assay are intended for use in the calculation of the HbA1c/total haemoglobin ratio (%HbA1c) and must not be used individually for diagnostic purposes.
In some methods falsely elevated % HbA1c results can be caused by the labile fraction of glycated haemoglobin (Schiff base). However this assay is not affected by "labile HbA1c" as the antibody used is specific for HbA1c(a stable ketamine).
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