Lactate assay
| Product | Method | Size | Catalog | Price | Quantity |
| Lactate assay | COLOR. | 380T | LC3980 | £85.25 | |
| Shipping costs will be added at the checkout stage, click here for charges. | |||||
- Material Safety Data Sheets
Intended Use
For the quantitative in vitro determination of L-Lactate in plasma and CSF. This test is specific for L-Lactate only. This product is suitable for use on RX Series instruments which includes the Rx Daytona and the Rx Imola.
Clinical Significance
Elevated levels of lactate are typical of any condition that decreases the amount of oxygen available to the body or increases the production of lactate within the body. Increased levels of lactate are commonly seen in a range of diseases including infections and metabolic disorders. Levels are also noticeably higher after exercise and after the use of some medicines including treatment for diabetes and tuberculosis.
Although lactate cannot be used to diagnose disease it can help to rule out possible causes. It can be used to distinguish between bacterial and viral meningitis as very high levels in CSF indicate bacterial meningitis whereas normal or slightly increased levels are associated with viral meningitis.
Principle
L-Lactate is one of the raw materials of glucogenesis produced by the active skeletal muscle and erythrocytes and is metabolised by the liver. When tissue cannot be supplied with sufficient oxygen to support aerobic oxidation of the pyruvate and NADH produced in glycolysis, NAD+ is regenerated from NADH by reduction of pyruvate to lactate. Increased concentration of lactate in the blood is thus an indicator of anaerobic metabolism ie. blood flow to the tissues decrease and oxygen delivery is insufficient. In cases of severe oxygen deprivation "Lactic Acidosis" may occur. L-Lactate may therefore be used as an indicator of severity of circulatory failure.
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