Magnesium assay
| Product | Method | Size | Catalog | Price | Quantity |
| Magnesium assay | Methylthy Blue | 120 tests | MG2817 | £106.25 | |
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- Format
Mixing and diluting are automatically performed by the Dimension® System. - Assay Range
0.164 - 9.59mmol/l - Working Stability 15-25 °C
_ - Working Stability 2-8 °C
_ - Material Safety Data Sheets
Intended Use
The MG method used on the Dimension® clinical chemistry system is an in vitro diagnostic test intended for the quantitative determination of magnesium in serum and urine. This product is suitable for use on the Siemens Dimension® analysers.
Clinical significance
Magnesium is one of the major intracellular cations in the body; its action is closely related to that of calcium.
Magnesium deficiency, hypomagnesaemia can result in various neuromuscular disorders, weakness, tremors, tetany and convulsions. Low levels in the blood are often associated with hypocalcaeia, intravenous therapy, diabetes mellitus, gastrointestinal disorders such as Crohn’s disease, hypoparathyroidism, alcoholism, dialysis and pregnancy.
Increased serum magnesium levels are associated with dehydration, severe diabetic acidosis, Addison's disease, hypothyroidism and hyperparathyroidism. Conditions that interfere with the glomerular filtration as in renal failure result in retention of magnesium and hence elevation of serum levels.
Principle
The magnesium method is a modification of the methylthymol blue (MTB) complexometric procedure described by Connerty, Lau, and Briggs.(1) The barium salt of ethylenebis (oxyethylenenitrilo) tetraacetic acid (Ba-EGTA) is used to reduce interference due to calcium which also reacts with MTB.(2)
MTB forms a blue complex with magnesium. Calcium interference is minimized by forming a complex between calcium and Ba-EGTA (chelating agent). The amount of MG-MTB complex formed is proportional to the magnesium concentration and is measured using a bichromatic (600 and 510 nm) endpoint technique.
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