Rheumatoid factor (complete kit with glass slides) assay
| Product | Method | Size | Catalog | Price | Quantity |
| Rheumatoid factor (complete kit with glass slides) assay | LATEX SLIDE TEST | 100T | RF2716 | £76.25 | |
| Shipping costs will be added at the checkout stage, click here for charges. | |||||
- Material Safety Data Sheets
Intended Use
Latex agglutination slide test for the qualitative and semi-quantitative in vitro determination of Rheumatoid Factor in serum. This product is suitable for manual use only.
Clinical Significance
The agglutination reaction between antibody coated red blood cells and Rheumatoid Arthritis (RA) sera was first demonstrated by Waaler and Rose in 1940. The reaction has since been shown to be caused by certain factors in the RA sera. Rheumatoid Factors (RF) are a heterogeneous group of high molecular weight auto antibodies directed against the body’s own immunoglobulins. They are produced by plasma cells present at sites of tissue injury. The initiating antigen is thought to be one or more viruses or viral antigens that persist in the joint tissues.
Research has shown that both environmental and genetic factors can affect the production of RF with various biological properties. RF has also been observed in the serum of patients with lupus erythematosus, hepatitis, liver cirrhosis, syphilis and various other conditions however the RF titre is much lower than in RA. Between 60 and 80% of patients with active Rheumatoid Arthritis (RA) possess this abnormal protein in their blood and joint fluid, and its detection is therefore of value in the diagnosis and monitoring of the disease.
Principle
The RF reagent contains latex particles coated with human gamma globulin. When the reagent is mixed with serum containing RF at a level greater than 8.0 IU/ml the particles will agglutinate. This is interpreted as being a positive sample.
The reagent may also be used for the semi-quantification of RF. For this purpose the sample is diluted over a range of dilutions and tested qualitatively. The RF level can be estimated from the last dilution with visible agglutination.
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