Rheumatoid factor (liquid) assay
| Product | Method | Size | Catalog | Price | Quantity |
| Rheumatoid factor (liquid) assay | LEI | R1 2x20, R2 2x8ml | RF3836 | £329.90 | |
| Shipping costs will be added at the checkout stage, click here for charges. | |||||
- Format
Liquid ready to use - Assay Range
6.72 - 104IU/ml - Working Stability 15-25 °C
_ - Working Stability 2-8 °C
Stable to expiry - Material Safety Data Sheets
Intended Use
For the quantitative in vitro determination of Rheumatoid Factors (RF) in serum. This product is suitable for use on the RX Series instruments which includes the Rx Daytona and Rx Imola.
Clinical Significance
The agglutination reaction between antibody coated red blood cells and Rheumatoid Arthritis (RA) sera was first demonstrated by Waaler and Rose in 1940. The reaction has since been shown to be caused by certain factors in the RA sera. These Rheumatoid Factors (RF) are a heterogeneous group of high molecular weight auto antibodies directed against the body’s own immunoglobulins. They are produced by plasma cells present at sites of tissue injury. The initiating antigen is thought to be one or more viruses or viral antigens that persist in the joint tissues.
Research has shown that both environmental and genetic factors can affect the production of RF with various biological properties. RF has also been observed in the serum of patients with lupus erythematosus, hepatitis, liver cirrhosis, syphilis and various other conditions however the RF titre is much lower than in RA. Between 60 and 80% of patients with active Rheumatoid Arthritis (RA) possess this abnormal protein in their blood and joint fluid, and its detection is therefore of value in the diagnosis and monitoring of the disease.
Principle
The Randox RF latex reagent is a suspension of polystyrene latex particles of uniform size coated with human IgG. When serum containing rheumatoid factor is mixed with the RF latex reagent an increase in turbidity can be measured at 550 nm. By constructing a standard curve from the absorbance of standards, the rheumatoid factor concentration can be determined.
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