Tpha assay
| Product | Method | Size | Catalog | Price | Quantity |
| Tpha assay | Haemaggluntination | 200 tests | SY1481 | £130.90 | |
| Shipping costs will be added at the checkout stage, click here for charges. | |||||
- Material Safety Data Sheets
Intended Use
For the quantitative in vitro determination of Treponema Pallidum in serum and plasma. This product is suitable for Manual use.
Clinical Significance
Syphilis is a chronic, contagious and often congenital venereal disease caused by Treponema pallidum. This organism belongs to a gram-negative group of bacteria called the Spirochetes, which are defined by their unique cellular structure. Infection results from contact with moist surfaces, originating in lesions of the epithelial tissue of the skin and mucous membranes. If untreated the disease may result in irreversible changes in the cardiovascular and nervous system. Syphilis remains a disease of high incidence, despite advances in modern antibiotic therapy.
Principle
The Syphilis TPHA test is an indirect haemagglutination test for the detection and titration of specific antibodies against Treponema pallidum. Avian erythrocytes are sensitised with antigens of the Nichol’s strain of Treponema pallidum. In the presence of syphilitic antibodies, these test cells aggregate to form characteristic patterns on the surface of the microplate wells. Antibodies directed against other nonpathogenic treponemes are absorbed by an extract of Reiter’s treponemes present in the cell suspensions, thus greatly reducing false positives. Other non-specific reactions can be detected and eliminated with the non-sensitised control cells.
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