Fibrinogen reagent assay
| Product | Method | Size | Catalog | Price | Quantity |
| Fibrinogen reagent assay | Coagulation | R1 6 x 1ml, R2 2 x 60ml | FIB2753 | £87.50 | |
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- Format
Lyophilised - Working Stability 15-25 °C
8 hours - Working Stability 2-8 °C
21 days - Material Safety Data Sheets
Intended Use
For the in-vitro quantitative determination of Fibrinogen by the clotting method of Clauss. This product is suitable for manual use or on a semi-automated analyzers.
Clinical Significance
Fibrinogen is a soluble plasma glycoprotein that is synthesised by the liver and is the most abundant clotting factor in plasma.
Fibrinogen is often used to assess whether or not fibrinogen levels are adequate to allow normal blood clotting, to determine if an individual has an inherited deficiency, to evaluate unexplained or prolonged bleeding and to evaluate the risk of both cardiovascular and heart disease.
Pathological changes in the concentration of Fibrinogen are found in many disease states. Decreased levels are associated with Hypofibrinogenemia, Afibrinogenemia, Disseminated Intravascular Coagulation (DIC), Liver diseases, viral hepatitis and Fibrinogenolysis. Increased Fibrinogen concentration is seen in chronic inflammatory illness, malignancy, surgery, trauma and cardiovascular disorders.
Principle
The Fibrinogen assay is based on the Clauss method. In the presence of a high concentration of Thrombin the time required for clot formation in diluted plasma is inversely proportional to Fibrinogen concentration.
- Manual
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