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Microalbumin assay

Product Method Size Catalog Price Quantity
Microalbumin assay Immunoturbidimetric 200 tests MA2864 $1003.60
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  • Format
    Mixing and diluting are automatically performed by the Dimension® System.
  • Working Stability 15-25 °C
    _
  • Working Stability 2-8 °C
    Stable to expiry
  • Material Safety Data Sheets
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Intended Use

For the quantitative in vitro determination of Microalbumin in human urine. This product is suitable for use on the Siemens Dimension® analyzers.


Clinical Significance

Kidney function may be assessed by measuring albumin levels in the urine. Normal kidney function entails filtering of waste products from the blood across tiny capillaries in the glomerulus.

Kidney malfunction results when the capillaries become blocked, causing waste products to remain in the blood and important proteins are lost from the blood into the urine.

Kidney deterioration is progressive and begins with small amounts of albumin leaking into the urine. This is known as microalbuminuria and indicates early signs of nephropathy. The term ‘micro-’ refers to low concentrations of urinary albumin. Progression of kidney disease will lead to larger amounts of albumin leaking into the urine which may develop further to end stage renal disease. Kidney disease is a major concern in diabetic patients and early detection and treatment may slow the onset and progression of the condition.

 

Condition     Albumin Levels (mg/day)
Normal    2-20
Microalbuminuria   20-300
Macroalbuminuria >300



Albumin is one of the major plasma proteins. In normal circumstances, albumin molecules are too large to cross the glomerular basement membrane; therefore, albumin is usually present at very low concentrations in the urine. Damage to the glomerular basement membrane can alter its permeability allowing albumin to enter the urine. Sustained elevation of urinary albumin concentrations is commonly referred to as Microalbuminuria.


Principle

This method is based on the reaction of a sample containing microalbumin and specific antiserum to form an insoluble complex that can be measured turbidimetrically at 340 nm. By constructing a standard curve from the absorbances of standards the concentration of microalbumin can be determined.


Available Applications

  • Dimension dedicated