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Alpha-1 acid glycoprotein assay

Product Method Size Catalog Price Quantity
Alpha-1 acid glycoprotein assay Immunoturbidimetric R1 3 x 16ml, R2 3 x 5ml AG2472 $761.00
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  • Format
    Liquid ready to use
  • Assay Range
    24.6 - 453mg/dl
  • Working Stability 2-8 °C
    Stable to expiry
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Intended Use

Immunoturbidimetric assay for the quantitative in vitro determination of alpha-1-acid-glycoprotein in human serum and plasma. This product is suitable for both manual and automated use. 

Clinical Significance
 
Alpha-1-acid-glycoprotein also known as Orosomucoid is an acute-phase reactant synthesized in the liver in response to inflammation and tissue damage. It functions as a carrier of basic and neutrally charged lipophilic compounds including basic drugs such as steroids.
 
The normal range for healthy individuals is 50-120 mg/dl however markedly higher levels are observed in a number of conditions such as inflammatory disease, acute myocardial infarction, trauma, malignancies, rheumatoid arthritis, chronic pain, bacterial infection, pregnancy and after surgery. Serum Alpha-1-acid-glycoprotein levels also provide a useful diagnostic tool in neonates with bacterial infections as most infected neonates produce increased levels.
 
Principle
 
Patient samples are diluted and reacted with a buffer containing antibody specific for alpha-1-acid-glycoprotein. The formation of the antibody-antigen complex during the reaction results in an increase in turbidity, the extent of which is measured as the amount of light absorbed at 340 nm. By constructing a standard curve from the absorbance of standards, the concentration of alpha-1-acid-glycoprotein can be determined.