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Alt (gpt) assay

Product Method Size Catalog Price Quantity
Alt (gpt) assay IFCC 5 x 20ml AL1268 $90.85
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  • Format
    Lyophilized
  • Assay Range
    7.99 - 500U/L
  • Working Stability 15-25 °C
    24 hours
  • Working Stability 2-8 °C
    14 days
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Intended Use
 
For the quantitative in vitro determination of Alanine Aminotransferase (ALT) in serum and plasma. This product is suitable for both manual and automated use.
 
Clinical Significance
 
The aminotransferases are a group of enzymes that catalyze the inter-conversion of amino acids and a oxoacids by transferring amino groups. The enzyme ALT (alanine aminotransferase or glutamate pyruvate transaminase) has been found to be in highest concentrations in the liver, with decreasing concentrations found in the kidneys, heart, skeletal muscle, pancreas, spleen and lung tissue respectively. 
 
ALT measurements are used in the diagnosis and treatment of certain liver diseases (e.g. viral hepatitis and cirrhosis) and heart diseases. Extremely elevated levels of ALT can indicate acute hepatitis with moderately high levels indicating chronic hepatitis. 
 
Elevated levels of the transaminases can also be indicative of myocardial infarction, hepatic disease, muscular dystrophy and organ damage. Elevated levels of ALT in serum is rare except in parenchymal liver disease, since ALT is a more liver specific enzyme.
 
ALT is often tested in combination with AST as part of a liver panel with ALT levels being higher in most types of liver disease

Principle
 
This is an optimized standard method according to the concentrations recommended by the IFCC.


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