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Apolipoprotein C-II (Apo C-II)

Product Method Size Catalog Price Quantity
Apolipoprotein C-II (Apo C-II) Immunoturbidimetric R1 2 x 11ml, R2 2 x 5ml LP3866 $946.23
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  • Format
    Liquid ready-to-use
  • Assay Range
    1.48 - 9.70mg/dl
  • Working Stability 2-8 °C
    Stable to expiry
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Intended Use

For the quantitative in vitro determination of Apolipoprotein C-II (Apo C-II) in serum and plasma. For use as an aid in assessing the risk of cardiovascular disease. This product is suitable for use on the RX series instruments which includes the RX daytona and RX imola.

Clinical Significance

Lipoproteins are large complexes of molecules that transport lipids (primarily triglycerides and cholesterols) through the blood. Apolipoproteins are proteins on the surface of the lipoprotein complex that bind to specific enzymes or transport proteins on the cell membranes. This directs the lipoprotein to the proper site of metabolism.

Apolipoprotein C-II is a 79 amino acid protein synthesised mainly in the liver and to a lesser extent in the intestine. Apo C-II acts as a co-factor for lipoprotein lipase, an enzyme that hydrolyses triglycerides in chylomicrons and VLDL. Patients have been identified with excessive hypertriglyceridemia due to a deficiency in Apo C-II. Deficient patients present with chylomicronemia, xanthomas, and recurrent pancreatitis. Apo C-II deficiency can be diagnosed biochemically by measuring Apo C-II levels.

Principle

This method is based on the reaction of a sample containing human Apo C-II and specific antiserum to form an insoluble complex which can be measured turbidimetrically at 340 nm.

Available Applications

RX series instruments, including:

RX daytona

RX imola