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Aso (complete kit with glass slides) assay

Product Method Size Catalog Price Quantity
Aso (complete kit with glass slides) assay LATEX SLIDE TEST 100T LO2715 $260.35
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Intended Use

Latex agglutination slide test for the qualitative and semi-quantitative determination of Anti-Streptomycin O (ASO) in human serum. Detection of ASO in serum may aid in the diagnosis of streptococcal infections. This test kit is for in vitro diagnostic use only. This product is suitable for Manual use only.


Clinical Significance

Streptomycin O (SLO) is a lethal, exocellular protein produced by Group A streptococci bacteria. It is so named because it is reversibly inactivated by atmospheric oxygen. The binding of active SLO to the surface of erythrocytes causes disruption of the cytoplasm membrane resulting in cell lysis. Anti-streptomycin O antibodies (ASO) are produced by the host to neutralize the hemolytic action of the SLO. Levels of ASO in serum are dependent on the age of the patient, geographical location and the local incidence of streptococcal infection.

Measurement of ASO in serum is used for the diagnosis of streptococcal infections such as rheumatic fever and glomerulonephritis. The ASO level can be used as a measure of the extent and degree of infection. Elevated ASO levels may also be present in other conditions such as scarlet fever, acute rheumatoid arthritis, tonsillitis and various other streptococcal infections and in healthy carriers.


Principle

The ASO reagent contains latex particles coated with streptomycin O antigen. When the reagent is mixed with serum containing ASO at a level greater than 200 IU/ml the particles will agglutinate. This is interpreted as being a positive sample.

For the semi-quantification of ASO the sample is diluted over a range of dilutions and each is tested qualitatively. The ASO level can be estimated from the last dilution with visible agglutination.



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