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Anti-Streptolysin-O 2 (ASO 2) assay

Product Method Size Catalog Price Quantity
Anti-Streptolysin-O 2 (ASO 2) assay Latex Enhanced Immunoturbidimetric R1 6 x 17.2ml, R2 6 x 28.4ml LO3999 $4317.84
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  • Format
    Liquid ready-to-use
  • Assay Range
    28.0 - 1314 IU/ml
  • Working Stability 2-8 °C
    Stable to expiry
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Intended Use

An ASO test system is a device intended for the quantitative in vitro determination of Anti-Streptolysin-O (ASO) concentration in serum. This product is suitable for use on the RX series instruments which includes the RX daytona and Rx imola.

Clinical Significance

Streptolysin O (SLO) is a lethal, exocellular protein produced by Group A streptococci bacteria. It is so named because it is reversibly inactivated by atmospheric oxygen.

The binding of active SLO to the surface of erythrocytes causes disruption of the cytoplasmic membrane resulting in cell lysis. Anti-streptolysin O antibodies (ASO) are produced by the host to neutralise the haemolytic action of the SLO.

Measurement of ASO in serum is used for the diagnosis of streptococcol infections such as rheumatic fever and glomerulonephritis. The ASO level can be used as a measure of the extent and degree of infection. Elevated ASO levels may also be present in other conditions such as scarlet fever, acute rheumatoid arthritis, tonsillitis and various other streptococcal infections and in healthy carriers.

Principle

In those infections promoted by acute streptococcal infection, antibodies to the exotoxin of streptococcus are usually produced. By reacting suspended uniform polystyrene particles coated with Streptolysin O together with serum containing antibodies, an increase in turbidity occurs. By comparing with a standard, a quantitative value for the concentration of Anti-Streptolysin O (ASO) present in serum can be obtained.

Available Applications

RX series instruments, including:

RX daytona

RX imola