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B2 Microglobulin (B2M) assay

Product Method Size Catalog Price Quantity
B2 Microglobulin (B2M) assay Immunoturbidimetric R1 2 x 11ml, R2 2 x 4.3ml BM3887 $797.99
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  • Format
    Liquid ready-to-use
  • Assay Range
    0.56 - 20.9mg/l
  • Working Stability 2-8 °C
    Stable to expiry
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Intended Use

Turbidimetric assay for the quantitative in vitro determination of B2Microglobulin in serum. This product is suitable for use on RX series instruments which includes the RX daytona and the RX imola.

Clinical Significance

2Microglobulin is a low molecular weight protein (11800D) found of the surface of all cells except erythrocytes and the trophoblastic layer of the placenta. It is a constituent of the light chain of human histocompatibility antigens HLA, A, B and C. B2M is found on T and B cells and in tumour associated transplantation antigens. B2M may control the expression of antigens on the cell surface and their biosynthesis.

In healthy individuals, B2M is synthesized at a rate of 9 mg/hours and is eliminated mostly by the kidneys.

In various myelomas, B2M levels have been related to tumour mass, prognosis, disease activity and effectiveness of treatment. Levels below 4 mg/l indicate better prognosis than levels above 20 mg/l.

Principle

2M present in patient samples reacts with the coated latex particles, causing an agglutination that can be measured at 546 nm. The increase in turbidity is proportional to the concentration of B2M in the sample.

Available Applications

RX series instruments, including:

RX daytona

RX imola