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Ceruloplasmin (CPL) assay

Product Method Size Catalog Price Quantity
Ceruloplasmin (CPL) assay Immunoturbidimetric R1 2 x 13.4ml, R2 2 x 4.8ml CPL4017 $271.31
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  • Format
    Liquid ready-to-use
  • Assay Range
    6.29 - 73.8mg/dl
  • Working Stability 2-8 °C
    Stable to expiry
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Intended Use

For the quantitative in vitro determination of Ceruloplasmin in human serum and plasma. This product is suitable for use on the RX series instruments which includes the RX daytona and Rx imola.

Clinical Significance

Ceruloplasmin is a blue-coloured α2-glycoprotein, synthesised mostly in the liver that binds 90 – 95% of blood plasma copper. The various functions of this protein include ferroxidase activity, amine oxidase activity, superoxidase activity and involvement in copper transport and homeostasis.

It is because of this last function that its primary use is in diagnosis of preclinical states of Wilson disease. In this condition Ceruloplasmin concentration is reduced and the inorganic copper ion is increased, because copper ions fail to re-enter the circulatory system as Ceruloplasmin. Copper is therefore deposited in the liver, cornea, kidney, bones and parathyroid glands. Wilson disease is fatal unless early treatment is instituted. Early detection is important, because therapy is effective in most cases.

Ceruloplasmin is also an acute-phase reactant protein whose concentration may rise to as high as three times the upper reference limit during bacterial infections. Concentrations are also raised in a variety of neoplastic and inflammatory conditions like carcinomas, leukaemia, Hodgkin disease, primary biliary cirrhosis, systemic lupus erythematosis and rheumatoid arthritis.

Principle

Anti-human ceruloplasmin antibodies, when mixed with samples containing ceruloplasmin, form insoluble complexes. These complexes cause an absorbance change, dependent on the ceruloplasmin concentration of the plasma sample that can be measured at 340nm. By constructing a standard curve from the absorbance of standards, the ceruloplasmin concentration can be determined.

Available Applications

RX series instruments, including:

Rx daytona

RX Imola