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Ck-mb assay

Product Method Size Catalog Price Quantity
Ck-mb assay Immunoinhibition R1 6 x 20ml, R2 3 x 10ml CK7946 $690.33
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  • Format
    Lyophilized
  • Assay Range
    9.1 - 1230 U/L
  • Working Stability 15-25 °C
    _
  • Working Stability 2-8 °C
    21 days
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Intended Use

For the quantitative in vitro determination of CKMB in serum and plasma. This product is suitable for use on the Hitachi 704, 705, 717, 902, 911 and 912.


Clinical Significance

Creatine Kinase (CK) is internationally accepted as a sensitive and specific indicator of acute myocardial infarction (AMI). There are 3 iso-enzymes of CK, CK-MM, CK-MB and CK-BB. CK-BB is produced by the brain in very small insignificant amounts. CK-MM is produced by the skeletal and heart tissue and CK-MB is produced by the heart muscle.

In the vast majority of cases CK activity rises within 6 hours of an acute infarction. After about 20 hours maximum CK values are observed. The CK activity generally returns to normal between the fourth and fifth day post- infarction.

Determination of CK activity in both plasma and serum can therefore provide a sensitive and specific marker for myocardial infarction, hyperthyroidism, kidney disease, cerebrovascular accidents and skeletal muscle diseases such as muscular dystrophy.

Elevated levels of CK are usually associated with damage to the heart or other muscles. It may also indicate excessive exercise or heavy use of the muscles.


Principle

Immunoinhibition Assay: An antibody is incorporated into the CK reagent. This antibody will bind to and inhibit the activity of the M subunit of CK-MB. This means that only the activity of the B subunit in serum is measured. If the activity is multiplied by a factor of 2, it will give the activity of CK-MB in serum.


Available Applications

  • Hitachi dedicated