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CK-MB assay

Product Method Size Catalog Price Quantity
CK-MB assay Immunoinhibition R1 6 x 20ml, R2 3 x 10ml CK7946 $690.33
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  • Format
    Lyophilised
  • Assay Range
    9.1 - 1230 U/L
  • Working Stability 2-8 °C
    Stable to expiry
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Intended Use

For the quantitative in vitro determination of CK-MB in serum and plasma. This product is suitable for use on the Hitachi 704, 705, 717, 902, 911 and 912.

Clinical Significance

Creatine Kinase (CK) is internationally accepted as a sensitive and specific indicator of acute myocardial infarction (AMI). There are 3 iso-enzymes of CK, CK-MM, CK-MB and CK-BB. CK-BB is produced by the brain in very small insignificant amounts. CK-MM is produced by the skeletal and heart tissue and CK-MB is produced by the heart muscle. In the vast majority of cases the CK activity rises within 6 hours of an acute infarction. After about 20 hours maximum values are observed. The CK activity generally returns to normal between the fourth and fifth day post-infarction.

Principle

Immunoinhibition Assay: An antibody is incorporated into the CK reagent. This antibody will bind to and inhibit the activity of the M subunit of CK-MB. This means that only the activity of the B subunit in serum is measured. If the activity is multiplied by a factor of 2, it will give the activity of CK-MB in serum.

Available Applications

Hitachi 704

Hitachi 705

Hitachi 717

Hitachi 902

Hitachi 911 / 912