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CK-MB assay

Product Method Size Catalog Price Quantity
CK-MB assay Immunoinhibition R1 6 x 21ml, R2 2 x 15ml CK9717 $747.66
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  • Format
    Lyophilised
  • Assay Range
    9.1 - 1230 U/L
  • Working Stability 2-8 °C
    Stable to expiry
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Intended Use

For the quantitative in vitro determination of CKMB in serum and plasma. This product is suitable for use on the Hitachi 917 and the Hitachi Modular P.

Clinical Significance

Creatine Kinase (CK) is internationally accepted as a sensitive and specific indicator of acute myocardial infarction (AMI). There are 3 iso-enzymes of CK, CKMM, CKMB and CKBB. CKBB is produced by the brain in very small insignificant amounts. CKMM is produced by the skeletal and heart tissue and CKMB is produced by the heart muscle. In the vast majority of cases the CK activity rises within 6 hours of an acute infarction. After about 20 hours maximum values are observed. The CK activity generally returns to normal between the fourth and fifth day post- infarction.

Principle

Immunoinhibition Assay: An antibody is incorporated into the CK reagent. This antibody will bind to and inhibit the activity of the M subunit of CK-MB. This means that only the activity of the B subunit in serum is measured. If the activity is multiplied by a factor of 2, it will give the activity of CK-MB in serum.

Available Applications

Hitachi 917

Hitachi Modular P