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Creatinine assay

Product Method Size Catalog Price Quantity
Creatinine assay Enzymatic 4 x 100ml CR2337 $1258.31
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  • Format
    Lyophilized
  • Assay Range
    Linear up to 1760umol/L
  • Working Stability 15-25 °C
    6 days
  • Working Stability 2-8 °C
    1 month
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Intended Use

For the quantitative in vitro determination of Creatinine in serum, plasma and urine. This product is suitable for both manual and automated use.


Clinical Significance

Creatinine is derived from creatine and creatine phosphate in muscle tissue and may be defined as a nitrogenous waste product. Creatinine is not reutilized but is excreted from the body in the urine via the kidney. It is produced and excreted at a constant rate which is proportional to the body muscle mass. As a consequence of the way in which creatinine is excreted by the kidney, creatinine measurement is used almost exclusively in the assessment of kidney function. Creatinine is regarded as the most useful endogenous marker in the diagnosis and treatment of kidney disease.

Creatinine is measured primarily to assess kidney function and has certain advantages over the measurement of urea. The plasma level of creatinine is relatively independent of protein ingestion, water intake, rate of urine production and exercise. Since its rate of production is constant, elevation of plasma creatinine is indicative of under-excretion, suggesting kidney impairment. Depressed levels of plasma creatinine are rare and not clinically significant.


Principle

Enzymatic UV method. Any endogenous ammonia present in the sample is removed by the presence of GLDH before the addition of creatinine deiminase. The reduction in absorbance at 340 nm caused by the oxidation of NADPH is proportional to the ammonia concentration released by creatinine.


Available Applications

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