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Creatinine assay

Product Method Size Catalog Price Quantity
Creatinine assay Jaffe 480T CR2804 $113.44
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  • Format
    Mixing and diluting are automatically performed by the DIMENSIONâ instrument.
  • Assay Range
    39.9 - 2221µmol/l
  • Working Stability 15-25 °C
    _
  • Working Stability 2-8 °C
    Stable to expiry
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Intended use

The CREA method used on the Dimension® clinical chemistry system is an in vitro diagnostic test intended for the quantitative determination of creatinine in serum, plasma and urine. This product is suitable for use on the Siemens Dimension® analyzers.


Clinical Significance

Creatinine is derived from creatine and creatine phosphate in muscle tissue and may be defined as a nitrogenous waste product. Creatinine is not re-utilized but is excreted from the body in the urine via the kidney. It is produced and excreted at a constant rate which is proportional to the body muscle mass. As a consequence of the way in which creatinine is excreted by the kidney, creatinine measurement is used almost exclusively in the assessment of kidney function. Creatinine is regarded as the most useful endogenous marker in the diagnosis and treatment of kidney disease.

Creatinine is measured primarily to assess kidney function and has certain advantages over the measurement of urea. The plasma level of creatinine is relatively independent of protein ingestion, water intake, rate of urine production and exercise. Since its rate of production is constant, elevation of plasma creatinine is indicative of under-excretion, suggesting kidney impairment. Depressed levels of plasma creatinine are rare and not clinically significant.


Principle

The creatinine method employs a modification of the kinetic Jaffe reaction reported by Larsen. This method has been reported to be less susceptible than conventional methods to interference from non-creatinine, Jaffe-positive compounds. Creatinine is generally regarded as the most useful endogenous substance to measure for the assessment of kidney function.