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Crp (complete kit with glass slides) assay

Product Method Size Catalog Price Quantity
Crp (complete kit with glass slides) assay LATEX SLIDE TEST 100T CP2714 $204.72
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Intended Use

Latex agglutination slide test for the qualitative and semi-quantitative in vitro determination of C-Reactive protein (CRP) in serum. This product is suitable for Manual use.


Clinical Significance

C-reactive protein received its name in 1930 when Tillet and Francis discovered a protein in the serum of patients with pneumonia that formed a complex with the C-polysaccharide of pneumococcus. It is one of the proteins commonly referred to as an acute phase reactant and provides a highly sensitive indicator of inflammatory conditions, infections and other disease states where tissue necrosis occurs.

C-reactive protein (CRP) is present in the serum of normal individuals at levels between 0 – 5 mg/l. After an acute episode CRP levels increase within four to six hours much earlier than other acute phase reactants which usually take more than 24 hours to produce a detectable signal in serum. In addition CRP levels return to normal quickly at the end of the acute episode.

Elevated levels outside the normal range are usually associated with acute phase response; measurements are therefore useful in the detection of infection, tissue injury, inflammatory disorders and associated diseases such as inflammatory bowel disease and rheumatic diseases.

Research has indicated that CRP levels, which are within the normal range, can be used in a variety of different population subgroups for the assessment of cardiovascular risk for developing a fatal myocardial infarction. CRP levels within the normal range have been associated with coronary heart disease mortality in high-risk individuals. Elevated serum cholesterol levels, elevated diastolic blood pressure and cigarette smoking indicate high risk.

A complete clinical history is required for accurate interpretation of CRP levels. CRP levels within the normal range may be affected by a number of different factors and should always be compared to previous values.


Principle

The CRP reagent contains latex particles coated with Anti-Human CRP antibody. When the reagent is mixed with serum containing CRP at a level greater than 6 mg/l the particles will agglutinate. This is interpreted as being a positive sample.

The reagent may also be used for the semi-quantification of CRP. For this purpose the sample is diluted over a range of dilutions and each is tested qualitatively. The CRP level can be estimated from the last dilution with visible agglutination.