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Crp full range (0.1-160 mg/l) assay

Product Method Size Catalog Price Quantity
Crp full range (0.1-160 mg/l) assay Immunoturbidimetric R1 4 x 50ml, R2 4 x 50ml CP3849 $4605.84
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  • Format
    Liquid ready to use
  • Assay Range
    0.3 - 161mg/l
  • Working Stability 15-25 °C
    _
  • Working Stability 2-8 °C
    Stable to expiry
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Intended Use

For the quantitative in vitro determination of C-reactive protein (CRP) concentration in serum or plasma. This product is suitable for use on the RX Series instruments which includes the Rx Daytona and Rx Imola.


Clinical Significance

C-reactive protein received its name in 1930 when Tillet and Francis discovered a protein in the serum of patients with pneumonia that formed a complex with the C-polysaccharide of pneumococcus. It is one of the proteins commonly referred to as an acute phase reactant and provides a highly sensitive indicator of inflammatory conditions, infections and other disease states where tissue necrosis occurs.

C-reactive protein (CRP) is present in the serum of normal individuals at levels between 0 – 5 mg/l. After an acute episode CRP levels increase within four to six hours much earlier than other acute phase reactants which usually take more than 24 hours to produce a detectable signal in serum. In addition CRP levels return to normal quickly at the end of the acute episode.

Elevated levels outside the normal range are usually associated with acute phase response; measurements are therefore useful in the detection of infection, tissue injury, inflammatory disorders and associated diseases such as inflammatory bowel disease and rheumatic diseases.

Research has indicated that CRP levels, which are within the normal range, can be used in a variety of different population subgroups for the assessment of cardiovascular risk for developing a fatal myocardial infarction. CRP levels within the normal range have been associated with coronary heart disease mortality in high-risk individuals. Elevated serum cholesterol levels, elevated diastolic blood pressure and cigarette smoking indicate high risk.

A complete clinical history is required for accurate interpretation of CRP levels. CRP levels within the normal range may be affected by a number of different factors and should always be compared to previous values.


Principle

Sample is reacted with a buffer and anti-CRP coated latex. The formation of the antibody-antigen complex during the reaction results in an increase in turbidity, the extent of which is measured as the amount of light absorbed at 570 nm. By constructing a standard curve from the absorbance of the standards, CRP concentration of sample can be determined.


Available Applications

  • Various