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Gamma gt assay

Product Method Size Catalog Price Quantity
Gamma gt assay Modified IFCC 288 Tests GT2815 $360.33
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  • Format
    Mixing and diluting are automatically performed by the DIMENSION® instrument.
  • Assay Range
    7.1 - 966U/L
  • Working Stability 15-25 °C
    _
  • Working Stability 2-8 °C
    Stable to expiry
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Intended Use

For the quantitative determination of γ-glutamyl transferase activity in serum and plasma. This product is suitable for use on the Siemens Dimension® analyzers.


Clinical Significance

Gamma-glutamyl transferase (γ-GT) in the serum originates primarily from the hepatobiliary system. Therefore γ-GT is elevated in all forms of liver disease and has been shown to be more sensitive than alkaline phosphatase in detecting obstructive jaundice, cholangitis and cholecystitis. High levels of γ-GT are also seen in patients with primary or secondary liver cancer. Increased levels are also observed in cases of alcohol abuse and in alcoholic liver cirrhosis.

In patients receiving anticonvulsant drugs such as Phenytoin and Phenobarbital, increased levels of the enzyme in serum may reflect induction of new enzyme activity and the toxic effects of alcohol and other drugs on the microsomal structures in liver cells. Although γ -GT is the most sensitive enzymatic indicator of hepatobiliary disease it can not be used to differentiate between different types of hepatobiliary disease. γ -GT however can be used in combination with other biochemical markers to discriminate between different types of hepatobiliary disease.


Principle

The γ-glutamyl transferase method is an adaptation of the methodology recommended by the International Federation of Clinical Chemistry (IFCC). The method uses the substrate L-gamma-glutamyl-3-carboxy-4-nitroanilide with glycylglycine.


Available Applications

  • Dimension dedicated