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Lipoprotein (a) assay

Product Method Size Catalog Price Quantity
Lipoprotein (a) assay Latex enhanced immunoturbidimetric R1 1 x 10ml, R2 1 x 6ml LP3403 $547.90
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  • Format
    Liquid ready to use
  • Assay Range
    3 - 90mg/dl
  • Working Stability 15-25 °C
    _
  • Working Stability 2-8 °C
    Stable to expiry
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Intended Use

Immunoturbidimetric assay for the quantitative in vitro determination of Lipoprotein (a) in human serum or plasma. This product is suitable for use on RX Series instruments which includes the Rx Daytona and Rx Imola.


Clinical Significance

Lipoprotein (a) [Lp(a)] is a low-density lipoprotein LDL-like particle with a cholesterol rich core and a molecule of apolipoprotein B-100 linked by a disulphide bridge to the glycoprotein Apolipoprotein (a) [Apo(a)]. The Lp(a) component varies in size ranging from 200 to 700kD and has structural similarities with plasminogen. Lp(a) competes with plasminogen for binding sites on the cell surface, decreasing plasminogen activation and inhibiting clot lysis, therefore promoting wound healing.

Lipoprotein (a) determination is intended for use in conjunction with clinical evaluation, patient risk assessment and other lipid tests to evaluate disorders of lipid metabolism and to assess coronary heart disease in specific populations. Elevated Lp(a) concentration in plasma is an independent genetic marker correlating with increased risk of atherosclerotic disorders including myocardial and cerebral infarction. Levels are also elevated in nephritic syndrome, patients undergoing renal dialysis, patients with uncontrolled diabetes mellitus and hypothyroidism.


Principle

Agglutination occurs due to an antigen-antibody reaction between Lp(a) in a sample and anti-Lp(a) antibody adsorbed to latex particles. This agglutination is detected as an absorbance change at 700 nm proportional to the concentration of Lp(a) in the sample.

Note: This product is licensed from Denka Seiken.


Available Applications

  • RX dedicated