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Lithium assay

Product Method Size Catalog Price Quantity
Lithium assay Colorimetric R1 2 x 18.3ml, R2 2 x 6.5ml LM4005 $921.83
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  • Format
    Liquid ready to use
  • Assay Range
    0.218 - 3mmol/L
  • Working Stability 15-25 °C
    _
  • Working Stability 2-8 °C
    14 days
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Intended Use

For the quantitative in vitro determination of Lithium in serum. This product is suitable for use on the RX Series instruments which includes the Rx Daytona and Rx Imola.


Clinical Significance

Lithium, administered as Lithium carbonate, is used for the treatment of the manic phase of affective disorders, mania, and manic-depressive illness. It acts by enhancing reuptake of neurotransmitters, thereby reducing their concentration in the neuronal junction. This produces a sedating effect on the central nervous system. It is completely absorbed by the gastro-intestinal tract and peak serum levels occur 2 to 4 hours after an oral dose. The half life in serum is 48 to 72 hours and is cleared through the kidneys. Reduced renal function can prolong clearance time.

Early symptoms of intoxification include apathy, sluggishness, drowsiness, lethargy, speech difficulties, irregular tremors, myoclonic twitchings, muscle weakness and ataxia. Levels higher than 1.5 mmol/l (12 hrs after a dose) indicate a significant risk of intoxification.

Serum lithium concentrations are carried out essentially to ensure compliance and to avoid toxicity.


Principle

Lithium method is based on the complexation of lithium ions with a Lithium-specific chromoionophore in an alkaline solution. The concentration of lithium in the sample is proportional to the increase in absorbance which is due to the formation of a lithium complex and is measured at a wavelength of 505nm.


Available Applications

  • Various