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Valproic acid assay

Product Method Size Catalog Price Quantity
Valproic acid assay LEI R1 2 x 15ml, R2 2 x 6ml TD3414 $640.33
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  • Format
    Liquid ready to use
  • Assay Range
    11.3 - 159ug/ml
  • Working Stability 15-25 °C
    _
  • Working Stability 2-8 °C
    Stable to expiry
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Intended Use

For the quantitative in vitro determination of Valproic Acid in human serum. This product is suitable for use on the RX Series instruments which includes the Rx Daytona and Rx Imola.


Clinical Significance


It is essential to maintain a constant concentration of medication in order for treatment to be successful, insufficient levels can mean drugs are not effective and excessive levels in some cases can lead to toxicity.

Often there is little difference between the dosage required for effective treatment and the dosage needed to cause severe side effects and even toxicity. The fact that individuals absorb, metabolize and make use of drugs at different rates means a standard dose cannot be prescribed for everyone. It is therefore extremely important to monitor the use of drugs with a narrow therapeutic range to ensure individuals are receiving the optimum treatment.

Valproic Acid is a widely used anti-epileptic drug. It is often used in the treatment of both primary and secondary generalized seizures as well as partial seizures.

Within the therapeutic range most individuals will respond well to treatment without any side effects. Measurements obtained are used in the diagnosis and treatment of valproic acid overdose and in monitoring levels of valproic acid to ensure appropriate therapy.


Principle

Randox Valproic Acid assay is a latex-enhanced immunoturbidimetric assay. It is based on the principle of measuring changes in scattered light. The latex particles are coated with valproic acid, which in the presence of valproic acid antibody solution, rapidly agglutinate.

When a sample containing valproic acid is introduced, the agglutination reaction is partially inhibited, slowing down the agglutination process. The rate of agglutination is inversely dependent upon the concentration of valproic acid in the sample. By monitoring the change in scattered light, as a change in absorbance, a concentration curve can be obtained. The actual change in absorbance is inversely proportional to the concentration of valproic acid in the sample.

This assay uses an end point method and multipoint calibration.


Available Applications

  • Various